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Heme-regulated eIF-2α kinase purifies as a hemoprotein

✍ Scribed by Peter Joseph Chefalo; Jihyun Oh; Maryam Rafie-Kolpin; Beki Kan; Jane-Jane Chen


Book ID
114429541
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
538 KB
Volume
258
Category
Article
ISSN
1432-1327

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Heme-regulated eukaryotic initiation factor (eIF)-2alpha kinase (HRI) regulates the synthesis of globin chains in reticulocytes with heme availability. In the present study, CO binding kinetics to the 6-coordinated Fe(II) heme of the amino-terminal domain of mouse HRI and resonance Raman spectra of