✍ Scribed by Michael K. Chan
No coin nor oath required. For personal study only.
The recent discovery that heme proteins can serve as molecular biosensors has opened up a new direction in heme biochemistry directed towards elucidating their structure-function relationships. Examples of such sensory heme proteins include the FixL proteins of Rhizobia involved in oxygen sensing, the CooA protein of Rhodospirillum rubrum that senses CO, and the mammalian soluble guanylate cyclase—the only proven nitric oxide receptor. This overview summarizes the current state of knowledge regarding the roles and mechanisms of these novel proteins and discusses the evidence for other putative heme protein sensors. These topics will be presented in the Heme Protein Biosensors Symposium at the First International Conference of Porphyrins and Phthalocyanines in Dijon, France.
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