Heme Oxygenase 2: Endothelial and Neuronal Localization and Role in Endothelium-Dependent Relaxation
โ Scribed by Randa Zakhary, Sean P. Gaine, Jay L. Dinerman, Martial Ruat, Nicholas A. Flavahan and Solomon H. Snyder
- Book ID
- 123639525
- Publisher
- National Academy of Sciences
- Year
- 1996
- Tongue
- English
- Weight
- 962 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/38549
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Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with โค-amyloid peptide (โค-AP 1-40 ) or hydrogen peroxide (H 2 O 2 ), we detected high levels of reactive oxygen species, accompanied by a significant
An increased expression of the inducible form of heme oxygenase (HO), HO-1, is found in the hippocampus after kainate injection, but thus far it is unclear whether the HO-1 is enzymatically active. The present study was carried out, using monoclonal antibodies to bilirubin and HO-1 and histochemical