The idea of using hematoporphyrin or hematoporphyrin derivative (HPD) in combination with light as a diagnostic and/or therapeutic modality for human cancer dates back to published work in the early 1960s. Lipson and Baldes [l] described the photodynamic properties of a hematoporphyrin derivative in
Hematoporphyrin-Derivative and Photoradiation Therapy of Malignant Tumors
β Scribed by James S. McCaughan Jr; Jerry T. Guy; Philip Hawley; William Hicks; William Inglis; Leslie Laufman; Eugene May; Thomas A. Nims; Rand Sherman
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 625 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0196-8092
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β¦ Synopsis
Kodak projectors with #2418 red Coming filters were used as a light source to treat cutaneous and subcutaneous malignancies in five patients who previously had been given hematoporphyrin derivative (HpD). An argon dye laser system was used to treat malignancies in patients who also were given the HpD. These tumors included 11 melanomas of the eye, three carcinomas of the esophagus, one melanoma of the esophagus, four carcinomas of the lung, three basal cell skin cancers, and one retropharyngeal metastatic oral cancer. Clinical results and technical problems of this therapy are discussed.
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Photoradiation therapy (PRT) with administration of hematoporphyrin derivative (HPD) was performed in ten cases of early stage central-type lung cancer of which six cases were treated by PRT alone due to inoperability because of poor pulmonary function in five and refusal of surgery in one. Four cas
The distribution of hematoporphyrin derivative (HPD) in the rat 9L gliosarcoma intracerebral brain tumor model at 4, 24, 48, and 72 hours after intravenous administration was evaluated using a digital video fluorescence microscopy technique. Maximum tissue fluorescence in the normal brain was observ
## Abstract Hematoporphyrin derivativeβphotoradiation therapy (HPDβPRT) of human malignancy has been performed on 267 tumor sites in 50 patients. Tumor response has been assayed at 24 hours and one month following treatment with 625β635 nm light from an argon laserβpumped dye laser. The majority of
Hematoporphyrin derivative-photoradiation therapy (HPD-PRT) was used to treat choroidal melanomas in 23 human subjects. Tumor sizes were divided into three categories: less than 500 mm3 (11 patients), 500-1,OOO mm3 (four patients), and greater than 1,OOO mm3 (eight patients). Tumors were exposed to