✦ LIBER ✦

Hematopoietic stem cells from mice with erythroblastosis

✍ Scribed by I. Hajdik; H. Niewisch; G. Matioli

Book ID: 102879976
Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 609 KB
Volume: 77
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040770314

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The infection of newborn mice with a mouse erythroblastotic virus increases the number of hematopoietic stem cells in the spleen. Upon retransplantation of these stem cells into intermediate recipient mice certain growth parameters (doubling time, self renewal and extinction probability, etc.) which are abnormal when measured by techniques which avoid the intermediate recipient step, appear to be reverted toward normal values. The “normalization” of the stem cells is explained by the change in the environment supporting CFU growth during transplantation.

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