✦ LIBER ✦

Immunodeficient mice as models of human hematopoietic stem cell engraftment

✍ Scribed by Mo A Dao; Jan A Nolta

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 65 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00006-0

No coin nor oath required. For personal study only.

✦ Synopsis

The past year has brought forth some exciting developments in the use of murine xenotransplantation systems to study the biology and transduction of human hematopoietic stem cells. The effects of cytokines have been studied by injection into the mice or by treatment of the cell inoculum prior to injection. The importance of the cell cycle and integrin expression has been evaluated. New methods of gene therapy have been tested in xenograft models -including cell cycle manipulation and a promising new lentiviral vector system, based on HIV.

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