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Helix–coil transition of poly-N5-(3-hydroxypropyl)-L-glutamine: Thermodynamic and statistical analysis

✍ Scribed by Noah Lotan; Mordechai Bixon; Arieh Berger

Publisher
Wiley (John Wiley & Sons)
Year
1969
Tongue
English
Weight
552 KB
Volume
8
Category
Article
ISSN
0006-3525

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✦ Synopsis

The thermally induced conformational changes of poly-iV5-(3-hydroxypropyl)-~glutamine in water and in methanol-water (3:7 v/v) have been analyzed in terms of the Lifson-Roig theory. The transitions in both solvents can be described by using u = 0.017. The thermodynamic parameters for the random coil-to-helix transition of one amino acid residue at room temperature were found to be: in water, AH = -130 cal/mole and A S = -0.45 e.u.; in methanol-water (3:i v/v), AH = -170 cal/mole and A S = -0.45 e.u. The size distribution of helical segments is broad, and the results of numerical calculations are presented for three degrees of polymerization (DP = 100, 300, and 750).

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