## Abstract Most cellular and viral processes depend on the coordinated formation of protein–protein interactions. With a better understanding of the molecular biology and biochemistry of human viruses it has become possible to screen for and detect inhibitors with activity against specific viral f
Helix-mediated protein–protein interactions as targets for intervention using foldamers
✍ Scribed by Thomas A. Edwards; Andrew J. Wilson
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 790 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Protein–protein interactions represent a highly populated class of targets for drug discovery. However, such systems present a number of unique challenges. This review presents an analysis of individual protein‐protein interaction systems which have recently yielded success in discoveri
## Abstract Although the structural analysis of membrane proteins is advancing, an understanding of the basic principles that underlie their folding and assembly remains limited because of the high insolubility intrinsic to these molecules and concomitant challenges in obtaining crystals. Fortunate
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases cause