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Helicobacter pylori polyclonally activates murine CD4+ T cells in the absence of antigen-presenting cells

✍ Scribed by Christine Rosenplänter; Frank Sommer; Peter Kleemann; Anna Belkovets; Annette Schmidt; Michael Lohoff


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
338 KB
Volume
37
Category
Article
ISSN
0014-2980

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CD4 ؉ CD25 ؉ regulatory T cells (Treg) are important mediators of peripheral immune tolerance; however, whether Treg participate also in hepatic immune tolerance is not clear. Therefore, we tested the potential of Treg to suppress stimulation of CD4 ؉ T cells by liver sinusoidal endothelial cells (L