Helicity Inversion in Lanthanide(III) Complexes with Chiral Nonaaza Macrocyclic Ligands

✍ Scribed by Janusz Gregoliński; Jerzy Lisowski

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 246 KB
• Volume: 118
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200602464

✦ Synopsis

Controlling the chirality of metal complexes or supramolecular assemblies continues to be a challenging and fascinating area of research. [1] The chirality of these systems may be related, for example, to the spatial disposition of chelating ligands around a metal ion, [1a] to the formation of double or triple helices, [2] to the helical twist of a macrocyclic ligand, [3] or to the rotation of the side arms of a macrocyclic ligand. [4] In favorable cases, these chiral compounds can be separated into enantiopure forms. [2c, 5] Alternatively, the enantiopure supramolecular assemblies and metal complexes can be obtained by diastereoselective synthesis from nonracemic chiral organic building blocks, which may determine the chirality of the assembly or complex (for example, the handedness of a helical structure). Generally, this strategy is successful when one of the possible diastereoisomers is thermodynamically favored. [6] In the case of DNA, however, diastereoisomeric structures of opposite helicity can be obtained from sugar