𝔖 Bobbio Scriptorium
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Helical protein design

✍ Scribed by Christian E Schafmeister; Robert M Stroud


Book ID
104362086
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
336 KB
Volume
9
Category
Article
ISSN
0958-1669

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✦ Synopsis


It is now possible to design small proteins capable of folding into compact structures with well-packed cores. Given the present state of knowledge of protein folding and design, it is possible to extract a set of engineering guidelines that may assist in future de novo protein design.


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Proteases play a key role in cellular biology and have become priority targets for new pharmaceuticals. Thus, there is a high demand for specific, sensitive, and quick assays to monitor the activity of endoproteases. We designed affinity-tagged helical proteins with unique protease cleavage sites an