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Computer Simulations of De Novo Designed Helical Proteins

✍ Scribed by Sikorski, Andrzej; Kolinski, Andrzej; Skolnick, Jeffrey


Book ID
119411360
Publisher
Biophysical Society
Year
1998
Tongue
English
Weight
271 KB
Volume
75
Category
Article
ISSN
0006-3495

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πŸ“œ SIMILAR VOLUMES


Computer simulations of the properties o
✍ Andrzej Sikorski; Andrzej Kolinski; Jeffrey Skolnick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 286 KB πŸ‘ 1 views

Reduced lattice models of the three de novo designed helical proteins ␣ 2 , ␣ 2 C, and ␣ 2 D were studied. Low temperature stable folds were obtained for all three proteins. In all cases, the lowest energy folds were four-helix bundles. The folding pathway is qualitatively the same for all proteins

Reversible assembly of helical filaments
✍ David W. H. Frost; Christopher M. Yip; Avijit Chakrabartty πŸ“‚ Article πŸ“… 2005 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 247 KB

## Abstract We have designed a series of 15 short, helical de novo peptides consisting of lysine, isoleucine, and alanine. We have termed this the KIA series. These peptides differ only in their hydrophobic interface, and thus their self‐association is largely a consequence of hydrophobic interacti