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Heilmittelchemische Studien in der heterocyclischen Reihe. 10. Mitteilung. Pyridazine VII. Zur neuen Pyridazin-Synthese. Methylpyridazine

✍ Scribed by P. Schmidt; J. Druey

Publisher
John Wiley and Sons
Year
1954
Tongue
German
Weight
307 KB
Volume
37
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Using methylglyoxal as the α‐dicarbonyl component in the new pyridazine synthesis described in an earlier publication, two isomeric methyl‐5‐cyano‐pyridazones‐(6) are obtained with cyanoacetic acid hydrazide. The position of the methyl groups has been proved.

📜 SIMILAR VOLUMES

Heilmittelchemische Studien in der heter
Heilmittelchemische Studien in der heterocyclischen Reihe. 19. Mitteilung. Pyridazine X. Cyan-pyridazin-Derivate mit analgetischer Wirkung
✍ P. Schmidt; J. Druey 📂 Article 📅 1957 🏛 John Wiley and Sons 🌐 German ⚖ 426 KB

## Abstract The analgetic activity of 1,3,4‐trimethyl‐5‐cyano‐pyridazone‐(6) (I), a compound chemically similar to the pyridine‐alkaloid ricinine is discussed. Many similar derivatives have been prepared, but only pyridazones having in position 5 a cyano, in 3 and 4 alkyl, and in 1 a methyl group h

Heilmittelchemische Studien in der heter
Heilmittelchemische Studien in der heterocyclischen Reihe. 5. Mitteilung. Pyridazine II. Eine neue Pyridazinsynthese
✍ P. Schmidt; J. Druey 📂 Article 📅 1954 🏛 John Wiley and Sons 🌐 German ⚖ 357 KB

## Abstract A new synthesis of 6‐pyridazones starting from three single components is described. The starting materials are (1) and α‐diketone, α‐ketoaldehyde or glyoxal, (2) a carbonic acid having an active methylene group in α‐position, and (3) hydrazine or a monosubstituted hydrazine.

Heilmittelchemische Studien in der heter
Heilmittelchemische Studien in der heterocyclischen Reihe. 23. Mitteilung. Pyridazine XI. Die Reaktion von Kojisäure mit Hydrazin. 1. Teil
✍ A. F. Thomas; A. Marxer 📂 Article 📅 1958 🏛 John Wiley and Sons 🌐 German ⚖ 350 KB

## Abstract It has been shown that the reaction between kojic acid and hydrazine hydrate gives rise to two main products: 3,6‐dihydroxymethyl‐4‐oxo‐1,4‐dihydro‐pyridazine, and the hydrazone of 3‐hydroxymethyl‐pyrazol‐5‐yl‐hydroxyacetaldehyde, the structures of which were proved unambiguously.