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Hedgehog Signaling Regulates Differentiation from Double-Negative to Double-Positive Thymocyte

✍ Scribed by Susan V Outram; Alberto Varas; Carmen V Pepicelli; Tessa Crompton

Book ID
117722372
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
698 KB
Volume
13
Category
Article
ISSN
1074-7613

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✍ Cesar Trigueros; Katsuto Hozumi; Bruno Silva-Santos; Ludovica Bruno; Adrian C. H πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 290 KB

The pre-T cell receptor (pre-TCR) and IL-7 receptor (IL-7R) are critical mediators of survival, proliferation and differentiation in immature thymocytes. Here we show that pre-TCR signaling directly maintains IL-7Ralpha expression as developing thymocytes undergo beta-selection. Inhibition of IL-7/I