Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte

Pre-TCR signaling regulates IL-7 recepto

Pre-TCR signaling regulates IL-7 receptor α expression promoting thymocyte survival at the transition from the double-negative to double-positive stage

✍ Cesar Trigueros; Katsuto Hozumi; Bruno Silva-Santos; Ludovica Bruno; Adrian C. H 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

The pre-T cell receptor (pre-TCR) and IL-7 receptor (IL-7R) are critical mediators of survival, proliferation and differentiation in immature thymocytes. Here we show that pre-TCR signaling directly maintains IL-7Ralpha expression as developing thymocytes undergo beta-selection. Inhibition of IL-7/I