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Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm

✍ Scribed by Elisabetta Ferretti; Enrico De Smaele; Lucia Di Marcotullio; Isabella Screpanti; Alberto Gulino


Book ID
116757982
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
203 KB
Volume
11
Category
Article
ISSN
1471-4914

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Loss of heterozygosity (LOH) on chromosome arm 17p is the most common genetic aberration in childhood primitive neuroectodermal tumors (PNETs). To determine the frequency and extent of 17p deletions, 29 loci on 17p were investigated in 24 tumors by using restriction fragment length polymorphism (RFL