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Heck Cross-Coupling of Aryldiazonium Tetrafluoroborate with Acrylates Catalyzed by Palladium on Charcoal

✍ Scribed by François-Xavier Felpin; Eric Fouquet; Cécile Zakri

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
336 KB
Volume
350
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A property‐activity relationship study of various palladium supported on charcoal (Pd/C) catalysts has been undertaken for the Heck reaction of aryldiazonium tetrafluoroborate with acrylates. The optimized protocol enables the cross‐coupling with a low loading of palladium at room temperature in technical grade methanol. Although the catalyst could not be recycled at this time, measurement of the palladium content by inductively coupled plasma mass spectrometry (ICP‐MS) shows low palladium contamination of the solvent and product, rendering this method safer for the environment compared to homogeneous conditions.

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✍ François-Xavier Felpin; Eric Fouquet; Cécile Zakri 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB 👁 1 views

## Abstract magnified image An improved Suzuki–Miyaura cross‐coupling reaction of aryldiazonium tetrafluoroborates with boronic acids catalyzed by a highly active palladium catalyst supported on charcoal is described as an extremely practical and efficient protocol. A properties‐activity study of