Heating reactivation of rats aminolevulinic acid dehydratase in lead poisoning
โ Scribed by A. Trevisan; M. Raimondi; A. Bungaro; P. Chiesura
- Book ID
- 119030530
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 154 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0048-9697
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๐ SIMILAR VOLUMES
Both blood lead and erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) activity were determined for workers with and without an occupational lead exposure. In workers occupationally exposed to lead, it was demonstrated that the erythrocyte ALA-D is markedly activated by heating the hemolysate
The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr