✦ LIBER ✦

Heat shock proteins in human endometrium throughout the menstrual cycle

✍ Scribed by S. Tabibzadeh; J. Broome

Publisher: Hindawi Publishing Corporation
Year: 1999
Tongue: English
Weight: 60 KB
Volume: 7
Category: Article
ISSN: 1064-7449
DOI: 10.1002/(sici)1098-0997(1999)7:1/2<5::aid-idog2>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

Human endometrium, in response to steroid hormones, undergoes characteristic cycles of proliferation, secretory changes, and tissue shedding. Human endometrium expresses a molecular repertoire which includes the heat shock proteins (Hsps) Hsp27, Hsp60, Hsp70, Hsp90, and alpha crystallin B chain. The expression of Hsp27, Hsp60, and the constitutive form of Hsp70 (Hsc70) shows a sharp increase in human endometrium after ovulation. The maximal expression of the molecular chaperone, alpha crystallin B chain, occurs during the secretory phase. In view of known functions of the Hsps, it is likely that these proteins are involved in protection of the endometrial proteins against factors with the potential to lead to protein denaturation. Tumor necrosis factor-␣ (TNF-␣) is a cytotoxic cytokine that is produced in progressive amounts during the secretory phase. The function of the Hsps may be to protect cells against the cytotoxic damage of TNF-␣, particu

📜 SIMILAR VOLUMES

Levels of 70-kDa heat shock protein thro

Levels of 70-kDa heat shock protein through the cell cycle in several mammalian cell lines

✍ Haiying Hang; Michael H. Fox 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB 👁 2 views

Seven different cell lines were analyzed by flow cytometry to d u a t e the variation i n heat shock protein hsp70 through the cell cycle. Inducible (hsp72) or both constitutive and inducible (hsp70) heat shock proteins were measured with monoclonal antibodies, and the cell cycle distribution was si

Menstrual cycle-dependent variations of

Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast

✍ John S. Silva; Gregory S. Georgiade; William G. Dilley; Kenneth S. McCarty; Samu 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB 👁 1 views

Detection of the human 70-kD and 60-kD h

Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: Relation to microbial flora, vaginal pH, and method of contraception

✍ P. Giraldo; A. Neuer; A. Ribeiro-Filho; I. Linhares; S.S. Witkin 📂 Article 📅 1999 🏛 Hindawi Publishing Corporation 🌐 English ⚖ 51 KB 👁 1 views

The expression of the 60-kD and 70-kD heat shock proteins (hsp60 and hsp70) in the vaginas of 43 asymptomatic women of reproductive age with or without a history of recurrent vulvovaginitis (RVV) were compared. Vaginal wash samples were obtained and assayed by enzyme-linked immunosorbent assay (ELIS