Heat of Hydrogenation of Compounds Containing Isolated and Conjugated CN Double Bonds

✍ Scribed by Prof. Dr. Günter Häfelinger; Dr. Ludger Steinmann

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 233 KB
• Volume: 16
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.197700471

✦ Synopsis

Compound ( I ) is heated with 1.5 mol. equiv. of hydroquinone and 2.5 mol. equiv. of potassium tert-butoxide in water (corresponding to 0.5 N KOH) under Nz for three weeks in a sealed tube at 110°C. Acidification of the reaction mixture, filtration, and washing of the filter cake neutral with water, followed by dissolution of the solid in ethyl acetate and chromatography of the filtered and concentrated solution on silica gel (ethyl