✦ LIBER ✦

Heat-induced cytotoxicity in H2O2-resistant Chinese hamster fibroblasts

✍ Scribed by Douglas R. Spitz; Gloria C. Li

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 590 KB
Volume: 142
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041420206

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✦ Synopsis

Hydrogen-peroxide-resistant Chinese hamster fibroblasts, derived from the HA-1 cell line, were isolated following continuous culturing in the presence of progressively increasing concentrations of hydrogen peroxide. The hydrogen-peroxide-resistant phenotype has been stable for over 360 days following removal from H, O, stress. These ti,O,-resistant cell lines demonstrate increased resistance to hypertherniic cell killing mediated by continuous heating at 43°C but not 45°C. The relationship between rnarnirndlian cellular adaptation to oxidative stress mediated by H,O, and resistance to 43°C hyperthermia is discussed.

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