Head-to-Tail Oxime Cyclization of Oligodeoxynucleotides for the Efficient Synthesis of Circular DNA Analogues
โ Scribed by Edupuganti, Om Prakash; Defrancq, Eric; Dumy, Pascal
- Book ID
- 126935825
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 54 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
An efficient and generally applicable method for the synthesis of head-to-tail cyclic peptides with HBTU (2-( lHbenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) has been developed. The utility of this approach was exemplified with the multigram preparation of a potent endothelin re
5ะ-Acetylthio-5ะ-deoxy-2ะ,3ะ-O-isopropylideneadenosine (8) was directly prepared from commercially available 2ะ,3ะ-Oisopropylideneadenosine ( 7) and thioacetic acid under Mitsunobu conditions in almost quantitative yield. In situ cleavage of the acetylthio function of 8 followed by coupling with dif