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HCV infection and liver cancer mortality in a Japanese population with HTLV-I

✍ Scribed by Sherri O. Stuver; Akihiko Okayama; Nobuyoshi Tachibana; Hirohito Tsubouchi; Nancy E. Mueller; Edward Tabor

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 333 KB
Volume: 67
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960703)67:1<35::aid-ijc8>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

In a cohort study of human T-lymphotropic virus type I (HTLV-I) infection in

Japan, 10 cases of liver cancer death occurred from 1984 through 1993. To analyze the role of hepatitis C virus (HCV), which has been associated with an increasing incidence of hepatocellular carcinoma (HCC) in Japan, a nested case-control study was performed. Five of the I0 liver cancer cases were positive for antibody to HTLV-I (anti-HTLV-I). The possible interaction between HCV and HTLV-I infections in the etiology of HCC was investigated, with each liver cancer case matched to 5 cohort controls by gender, age, serum sample date and anti-HTLV-l status. Using a matched analysis, odds ratios (OR) were generated for the relationship between HCV serologic status and death from liver cancer.

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