✦ LIBER ✦

Harmonized microarray/mutation scanning analysis of TP53 mutations in undissected colorectal tumors

✍ Scribed by Reyna Favis; Jianmin Huang; Norman P. Gerry; Alfred Culliford; Philip Paty; Thierry Soussi; Francis Barany

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 582 KB
Volume: 24
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.20069

No coin nor oath required. For personal study only.

✦ Synopsis

Communicated by

📜 SIMILAR VOLUMES

Integrating mutation data and structural

Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

✍ Andrew C.R. Martin; Angelo M. Facchiano; Alison L. Cuff; Tina Hernandez-Boussard 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 678 KB

Communicated by

Mutation analysis of CDP, TP53, and KRAS

Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas

✍ Maria I. Patrikis; Emma J. Bryan; Nicola A. Thomas; Greg E. Rice; Michael A. Qui 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 85 KB

## Abstract Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular pathology. We used single‐stranded conformational polymorphism/heteroduplex analysis to analyze 42 unselected uterine leiomyomas for somatic mutations in all coding exons of the ge

Significance of TP53 mutations in human

Significance of TP53 mutations in human cancer: A critical analysis of mutations at CpG dinucleotides

✍ Thierry Soussi; Christophe Béroud 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 1 views

A detailed analysis of p53 (TP53) mutations involving the 42 CpG dinucleotides was performed to gain greater insight into the mutational mechanism leading to specific selection of these mutations. Although the majority of these CpG dinucleotides have been found to be mutated in cancer cells, the het

Somatic mutations of the APC, KRAS, and

Somatic mutations of the APC, KRAS, and TP53 genes in nonpolypoid colorectal adenomas

✍ René van Wyk; Premysl Slezak; Vanessa M. Hayes; Charles H.C.M. Buys; Maritha J. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB 👁 2 views

Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenomacarcinoma sequence were primarily based on DNA studies of

Analysis ofTP53 germline mutations in pe

Analysis ofTP53 germline mutations in pediatric tumor patients using DNA microarray-based sequencing technology

✍ Schaefer, Karl-Ludwig ;Wai, Daniel ;Poremba, Christopher ;Diallo, Raihanatou ;Bo 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB

## Abstract ## Background Whereas in sporadic human malignancies mutations of the __TP53__ tumor‐suppressor gene occur in cancers of almost every organ and histologic subtype, patients with an inborn __TP53__ defect are at high risk to develop, in particular, soft tissue and bone sarcomas, brain t

Novel mutations of the suppressor gene P

Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status

✍ Stine A. Danielsen; Guro E. Lind; Merete Bjørnslett; Gunn I. Meling; Torleiv O. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB

In conclusion, PTEN contributes in maintaining normal cell homeostasis, and the numerous alterations found in several sporadic tumor types emphasize the significance of this tumor suppressor gene. Somatic PTEN mutations appear to play an important role in the development of a subgroup of sporadic co