𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status

✍ Scribed by Stine A. Danielsen; Guro E. Lind; Merete Bjørnslett; Gunn I. Meling; Torleiv O. Rognum; Sverre Heim; Ragnhild A. Lothe

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
69 KB
Volume
30
Category
Article
ISSN
1059-7794

No coin nor oath required. For personal study only.

✦ Synopsis

In conclusion, PTEN contributes in maintaining normal cell homeostasis, and the numerous alterations found in several sporadic tumor types emphasize the significance of this tumor suppressor gene. Somatic PTEN mutations appear to play an important role in the development of a subgroup of sporadic colorectal cancer, and we here describe 16 novel acquired PTEN mutations in this tumor type. As has been reported for other cancers, mutations of PTEN and TP53 appear to be a mutually exclusive event also for cancer of the large bowel.

📜 SIMILAR VOLUMES

Novel mutations of the suppressor gene P
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status
✍ Stine A. Danielsen; Guro E. Lind; Merete Bjørnslett; Gunn I. Meling; Torleiv O. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB

## Communicated by Albert de la Chapelle PTEN regulates cell homeostasis by inhibiting growth signals transduced through PI3kinases. The gene is mutated in several cancer types, but so far, only a limited number of mutations have been reported in colorectal cancer. In the present study, direct seq

Allelic loss of chromosome 17p, mutation
Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right- and left-sided colorectal cancer
✍ Masahiro Watatani; Toshihiro Yoshida; Kosaku Kuroda; Shintaro Ieda; Masayuki Yas 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 575 KB

## BACKGROUND. Epidemiologic and genetic studies suggest that cancer of the right and left sides of the bowel arise through different mechanisms. To investigate the molecular mechanisms, allelic loss of chromosome 17p, p53 mutations, and microsatellite instability were analyzed in colorectal cance