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Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia

✍ Scribed by Schwab, S G; Wildenauer, D B; Martinez, M; Gejman, P V; Sanders, A R; Rusu, I; Duan, J; Molen, J E Vander; Hou, C

Book ID: 110059871
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 170 KB
Volume: 10
Category: Article
ISSN: 1359-4184
DOI: 10.1038/sj.mp.4001586

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## Abstract Several lines of evidence suggest that psychosis is associated with altered dopaminergic neurotransmission. Dopamine is catabolized by monoamine oxidase (MAO) and catechol‐O‐methyl transferase (COMT). We hypothesized that the genes encoding MAOA and COMT might contain genetic variation