Recent reports have strongly linked markers near the β£-7 nicotinic cholinergic receptor subunit gene on human chromosome 15q13-q14 to a sensory gating deficit common in schizophrenics, and have shown positive though non-significant results linking this region to the primary phenotype of schizophrenia in a sample of North American families. We therefore tested for linkage between markers in this region of chromosome 15q and schizophrenia in a sample of 15 multiply affected and 5 single case families with schizophrenia drawn from the Bantu-speaking black population of South Africa. An initial replication using markers from the original study gave an affectedonly LOD score maximum of 1.08 under a recessive model at β°=0.00 for D15S1360, a dinucleotide polymorphism found on the same YAC as the β£-7 receptor gene. Nonparametric affected-only multipoint analysis gave a Z-score of 1.29, P=0.098, for D15S1360, and Z=1.45, p=0.075 for D15S118. We then increased the resolution of the map with an extended set of 20 markers. Again, two peaks were observed, with NPL scores of 1.81, p=0.037, at D15S1043 and 1.79 at D15S1360 and 1.80 at D15S1010, both p=0.037. Transmission disequilibrium testing of data from D15S1360 gave an allelewise and genotype-wise 2 of 6.59, 2 df, p=0.037. Haplotype transmission disequilibrium testing using a restricted allele and haplotype set from D15S1043 and D15S1360 gave a global 2 of 10.647, 4 df, P=0.007, and a maximum 2 of 6.567, 1 df, P=0.004 for excess transmission of the 1.2