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Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: A case–control study

✍ Scribed by Chunying Li; Zhensheng Liu; Li E. Wang; Jeffrey E. Gershenwald; Jeffrey E. Lee; Victor G. Prieto; Madeleine Duvic; Elizabeth A. Grimm; Qingyi Wei

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
147 KB
Volume
122
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In a hospital‐based case–control study of 805 non‐Hispanic whites with cutaneous melanoma and 841 cancer‐free age‐, sex‐ and ethnicity‐matched control subjects, 3 VDR polymorphisms (i.e., __Taq__I, __Bsm__I and __Fok__I) were genotyped using blood samples collected between 1994 and 2006. We tested the hypothesis that the haplotypes and combined genotypes of these polymorphisms were associated with melanoma risk by interacting with known risk factors. Haplotypes t‐B‐F (adjusted odds ratio [OR], 0.52; 95% confidence interval [CI], 0.34–0.80) and t‐B‐f (adjusted OR, 0.51; CI, 0.27–0.94) were associated with a reduced risk when compared to T‐b‐f. The combined genotypes Tt+tt/Bb+BB/Ff+ff (adjusted OR, 0.69; CI, 0.52, 0.90) and Tt+tt/Bb+BB/FF (adjusted OR, 0.58; CI, 0.43, 0.78) were also associated with reduced risk, whereas the combined genotype TT/Bb+BB/Ff+ff genotype (adjusted OR, 2.35; CI, 1.13, 4.98) was associated with increased risk when compared to TT/bb/Ff+ff genotypes. On multivariate analysis, only the __Taq__I polymorphism was an independent risk factor, while the __Fok__I polymorphism interacted with skin color (p = 0.029), moles (p = 0.017) and first‐degree relatives with any cancer (p = 0.013) in modifying risk. Together, these findings suggest that VDR polymorphisms may directly affect or modify the risk associated with known melanoma risk factors. Larger, population‐based studies are needed to replicate our findings. © 2008 Wiley‐Liss, Inc.

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