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Haploscleridamine, a Novel Tryptamine-Derived Alkaloid from a Sponge of the Order Haplosclerida: An Inhibitor of Cathepsin K

✍ Scribed by Patil, Ashok D.; Freyer, Alan J.; Carte, Brad; Taylor, Paul B.; Johnson, Randall K.; Faulkner, D. John


Book ID
115465167
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
29 KB
Volume
65
Category
Article
ISSN
0163-3864

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## Abstract Two stereoisomers of penazetidine A (1a), the azetidine alkaloid isolated from the Indo‐Pacific marine sponge __Penares sollasi__, were synthesized by starting from (__S__)‐serine and (__R__)‐or (__S__)‐citronellol. The natural penazetidine A must be either (2__S__,3__R__,4__S__,12β€²__R_