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Haploinsufficiency of AML1 Affects the Temporal and Spatial Generation of Hematopoietic Stem Cells in the Mouse Embryo

✍ Scribed by Zhongling Cai; Marella de Bruijn; Xiaoqian Ma; Bjorn Dortland; Tanya Luteijn; James R Downing; Elaine Dzierzak

Book ID
117722395
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
480 KB
Volume
13
Category
Article
ISSN
1074-7613

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## Abstract Lineage‐specific transcription factors must be precisely regulated during stem cell self‐renewal and lineage commitment decisions. The role of specific transcription factors in hematopoietic stem cell (HSC) fate decisions has derived largely from genetic strategies, primarily gene‐targe