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Handling Marker-Marker Linkage Disequilibrium: Pedigree Analysis with Clustered Markers

✍ Scribed by Gonçalo R. Abecasis; Janis E. Wigginton


Book ID
117854684
Publisher
American Society of Human Genetics
Year
2005
Tongue
English
Weight
604 KB
Volume
77
Category
Article
ISSN
0002-9297

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Linkage disequilibrium (LD) is a potentially powerful tool for the localization of disease genes for complex disorders. Most prior studies of the relationship between genetic distance and LD have examined only very short distances, focusing on the role of LD in fine-mapping and positional cloning. W