Handicap in Darier's disease and Hailey-Hailey disease
✍ Scribed by A. HARRIS; S.M. BURGE; P.J. DYKES; A.Y. FINLAY
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 372 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0007-0963
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In order to clarify the pathomechanism of acantholysis in Hailey-Hailey disease (HHD) and Darier's disease (DD), the distribution of desmosomal and adherens junction-associated proteins was studied in the skin of patients with HHD (n = 4) and DD (n = 3). Domain-specific antibodies were used to deter
## Abstract A 61–year-old woman, who was known to have Hailey–Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This