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[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy

โœ Scribed by Francis, Sharron H.; Conti, Marco; Houslay, Miles D.

Book ID
118152597
Publisher
Springer Berlin Heidelberg
Year
2011
Weight
303 KB
Category
Article
ISBN
364217969X

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[Handbook of Experimental Pharmacology]
[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases
โœ Francis, Sharron H.; Conti, Marco; Houslay, Miles D. ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Springer Berlin Heidelberg ๐ŸŒ German โš– 201 KB

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that