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Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay

โœ Scribed by David E. Amacher; Simone C. Paillet

Book ID
113192234
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
581 KB
Volume
106
Category
Article
ISSN
0027-5107

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In previously described activation systems [Clive D, Spector : Mutat Res 31:17-291 for the mouse lymphoma mutation assay the cofactor isocitrate is rapidly exhausted and the resultant loss of NADPH can halt metabolic processes. Presented here are data obtained with a nontoxic b'olance of NADP (1.4 m