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Hammerhead ribozyme–mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma

✍ Scribed by Gabriele Hübinger; Engelbert Wehnes; Liquan Xue; Stephan W Morris; Ulrich Maurer

Book ID: 114216981
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 307 KB
Volume: 31
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(02)01084-6

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## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel

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