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Hammerhead ribozyme targeting human platelet-derived growth factor A-chain mRNA inhibited the proliferation of human vascular smooth muscle cells

โœ Scribed by Wen-Yang Hu; Noboru Fukuda; Hirobumi Kishioka; Mari Nakayama; Chikara Satoh; Katsuo Kanmatsuse


Book ID
119435239
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
606 KB
Volume
158
Category
Article
ISSN
0021-9150

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Proliferation of smooth muscle cells from the pulmonary arteries and aortas of fetal calves is inhibited by heparin in vitro. This effect is reversible and dose dependent. Comparisons with effects of other polysaccharides indicate that only extensively sulfated polysaccharides inhibit proliferation