## Abstract Pharmacokinetics of haloperidol in the rat following intravenous bolus doses of 0ยท5, 1ยท0, and 2ยท5 mg kg^โ1^, respectively, were investigated. It was found that haloperidol was a high extraction ratio drug with a total blood clearance averaging 83 ml min^โ1^ kg^โ1^. The volumes of distri
Haloperidol and light reinforcement in the rat
โ Scribed by G. Lowe
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 200 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0033-3158
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โฆ Synopsis
The effect of the anti-psychotic drug, haloperidol (50 mg/kg), on bar pressing in the rat was investigated in a light-reinforcement situation. Drugged animals responded significantly more for response contingent flickering light (RCF) and less for steady light (RCL) than saline injected animals. The finding is consistent with the possible arousal decreasing action of haloperidol and with the notion of an optimum level of arousal.
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Rats were trained in a complex maze task for food reward. After a 25-day retention interval, they made more errors than at the last training trials. This forgetting was alleviated by pretest treatment with haloperidol. The same dose of haloperidol had no effect on acquisition or performance when inj
Hallucinogenic drugs may produce changes in the neurophysiological response to sensory input, and it is suggested that corresponding behaviourM changes may be monitored by an animal's reaction to response contingent visual stimulation. LSD-25 was shown to depress responding in rats for light onset a