## Abstract Convergent syntheses of the 9‐(3‐X‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranosyl)adenines **5** (X=N~3~) and **7** (X=NH~2~), as well as of their respective __α__‐anomers **6** and **8**, are described, using methyl 2‐azido‐5‐__O__‐benzoyl‐2,3‐dideoxy‐2‐fluoro‐__β__‐D‐ribofuranoside (**4**
Halogenated 7-Deazapurine Nucleosides: Stereoselective Synthesis and Conformation of 2′-Deoxy-2′-fluoro-β-D-arabinonucleosides.
✍ Scribed by Xiaohua Peng; Frank Seela
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 32 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (
## Abstract Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐__β__‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** with protected uracil derivatives **3a–e** followed by hydrolysis and high‐performance liquid
The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C