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Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes

✍ Scribed by Borroto-Escuela, Dasiel O.; Romero-Fernandez, Wilber; Narvaez, Manuel; Oflijan, Julia; Agnati, Luigi F.; Fuxe, Kjell


Book ID
122315224
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
892 KB
Volume
443
Category
Article
ISSN
0006-291X

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Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum