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Dynamic modulation of FGFR1–5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

✍ Scribed by Borroto-Escuela, Dasiel O.; Corrales, Fidel; Narvaez, Manuel; Oflijan, Julia; Agnati, Luigi F.; Palkovits, Miklós; Fuxe, Kjell


Book ID
121332174
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
992 KB
Volume
441
Category
Article
ISSN
0006-291X

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Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum