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Haliclonadiamine, an antimicrobial alkaloid from the sponge Haliclona SP

✍ Scribed by Eoin Fahy; Tadeusz F. Molinski; Mary Kay Harper; Brian W. Sullivan; D.John Faulkner; Laszlo Parkanyi; Jon Clardy

Book ID
107858425
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
165 KB
Volume
29
Category
Article
ISSN
0040-4039

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The haliclonacyclamines, cytotoxic terti
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2D-NMR spectroscopic data is reported for the haliclonacyclamines A -D (1)-( ) and for two bismethiodide adducts ($) and ( ). The structures of two new alkaloids, halicionacyclamines C (3) and D (4), which are the 15,16-dihydro analogues of the haliclonacyclamines A (1) and B (2) are described. Revi

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The title compounds were isolated from a marine sponge collected off Okinawa. Their structures were determined by X-ray and shown to be I-/&carbolines. Manzamine C was the 2-ethyl-N-azacycloundec-6-ene derivative, whereas manzamine B was more complex being the epoxy isomer of the free base of dihydr