Half-life of N-acetylprocainamide in rats
β Scribed by Burde L. Kamath; Avraham Yacobi
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 263 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
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The pharmacokinetics of N-acetylprocainamide, administered orally or intravenously, were studied in 3-, 6-, and 12-month-old rats using a two-way crossover study design. At 3, 6, and 12 months of age, the half-life values of N-acetylprocainamide were 1.66, 1.82, and 2.29 hr, respectively; the appare
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.