✦ LIBER ✦
Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan
✍ Scribed by Gollamudi Ramachander; K. R. Bapatla; Jane Frances Emele
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 233 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.