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H-ras Induces Glucose Uptake in Brown Adipocytes in an Insulin- and Phosphatidylinositol 3-Kinase-Independent Manner

✍ Scribed by Angela M. Valverde; Paloma Navarro; Manuel Benito; Margarita Lorenzo


Book ID
115603026
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
586 KB
Volume
243
Category
Article
ISSN
0014-4827

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Inhibition of PI 3-kinase and RAS blocks
✍ Teresa Teruel; Angela M. Valverde; Paloma Navarro; Manuel Benito; Margarita Lore πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 324 KB

Fetal brown adipocytes expressed uncoupling protein 1 (UCP1) mRNA, this expression being blunted throughout culture for 24 h in a serum-free medium. At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1