H-2U: A new region at theDend of the murine MHC

✍ Scribed by H. C. O'Neill; C. R. Parish

• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 795 KB
• Volume: 13
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00350791

✦ Synopsis

A new genetic region, mapping within the H-2 complex, has been serologically defined with several alloantisera raised in mice which differ at the D region. When these antisera were absorbed to remove H-2D antibodies, residual antibody activity remained that reacted in a strain-specific manner, and the antigens involved mapped to a new genetic region between the S and D regions. Two allelic variants relating to the d and k haplotypes have been defined by genetic mapping studies. This new region has been designated H-2U and the antigens it controls appear to resemble Ia antigens in their cellular distribution and molecular weight. The new antigen is primarily expressed on B cells, and is carried on protein molecules having approximate molecular weights of 36 000 and 60 000 daltons and resembling the ~ and c~-/~ chain dimer characteristic of Ia antigens.

* Titer expressed as reciprocal diiution of antiserum at which rosetting reached 50 percent of peak value.