𝔖 Bobbio Scriptorium
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Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

✍ Scribed by Javier Ochoa-Repáraz; Daniel W. Mielcarz; Sakhina Begum- Haque; Lloyd H. Kasper

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
187 KB
Volume
69
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

✦ Synopsis

The mammalian gastrointestinal track harbors a highly heterogeneous population of microbial organisms that are essential for the complete development of the immune system. The gut microbes or ''microbiota,'' coupled with host genetics, determine the development of both local microbial populations and the immune system to create a complex balance recently termed the ''microbiome.'' Alterations of the gut microbiome may lead to dysregulation of immune responses both in the gut and in distal effector immune sites such as the central nervous system (CNS). Recent findings in experimental autoimmune encephalomyelitis, an animal model of human multiple sclerosis, suggest that altering certain bacterial populations present in the gut can lead to a proinflammatory condition that may result in the development of autoimmune diseases, in particular human multiple sclerosis. In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, can protect against inflammation within the CNS.

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