GUINEA PIG MODEL FOR CUTANEOUS HERPES SIMPLEX VIRUS INFECTION.
β Scribed by Hubler, Jr., W. R.; Felber, Troy D.; Troll, Douglas; Jarratt, Michael
- Book ID
- 110689567
- Publisher
- Nature Publishing Group
- Year
- 1974
- Tongue
- English
- Weight
- 618 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-202X
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Cutaneous infection of guinea pigs with HSV1 was topically treated from 2 to 6 days post infection with 7 antiherpetic substances. Phosphonoformic acid and acyclovir were found to be highly effective; trifluorothymidine, thymine arabinoside, ethyldeoxyuridine, and adenine arabinoside monophosphate a
## Abstract Factors that influence the outcome of genital herpes simplex virus (HSV) infection were explored in a guinea pig model. The viral inoculum required to establish infection in 50% of animals (ID~50~) was similar for inbred (strain 2) and outβbred (Hartley) guinea pigs. However, the viral