Guidelines for nomenclature of genetically determined biochemical variants in the house mouse,Mus musculus

✍ Scribed by Committee on Standardized Genetic Nomenclature for Mice

• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 299 KB
• Volume: 9
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00486072

✦ Synopsis

The recent vast increase in the rate of discovery of genetically determined biochemical variants in mice has necessitated the selection of many new symbols to designate the new genetic loci and alleles. The existing rules for gene nomenclature in mice (Committee, 1963) specify general rules for gene names and symbols, allelic differences, kinds of type to be used in print, etc. Because these rules were designed to cover the many kinds of existing mutations of mice, including mutations causing coat color differences, pathological conditions, behavioral abnormalities, histoincompatibility, and the like, as well as enzyme variations, the rules offer several alternatives in the choice of new symbols. This has led to some variation in usage among those concerned with the choice of symbols for biochemical variants.

Since biochemical variants constitute a somewhat distinct class of mutations, it seems desirable to standardize usage within this field as much as possible. At the instigation of Dr. John J. Hutton, who drafted the original version, the Committee on Standardized Genetic Nomenclature for Mice has therefore prepared the following set of Guidelines to assist investigators in choosing appropriate names and symbols for new loci affecting enzymes and other biochemical characteristics of mice.