Construction of human linkage maps: Like
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Dr. G. M. Lathrop; J. M. Lalouel; R. L. White; D. C. Rao
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Article
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1986
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John Wiley and Sons
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English
β 772 KB
Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an ap