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Construction of human linkage maps: Likelihood calculations for multilocus linkage analysis

✍ Scribed by Dr. G. M. Lathrop; J. M. Lalouel; R. L. White; D. C. Rao

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 772 KB
Volume: 3
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370030105

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✦ Synopsis

Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.

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